Christopher Reid

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Faculty Suite B, Room 333

Christopher Reid

My interests lie at the interface of chemistry and microbiology. During my sophomore year i discovered my interest in chemistry through my introductory organic chemistry and physical chemistry courses. This interest was later fused with biology and in particular microbiology by the time I finished my undergraduate degree. I moved to the University of Waterloo to complete a MSc in chemistry studying non-natural amino acid and peptide synthesis. It is during this time that I was introduced to biological mass spectrometry, a discipline that has followed be ever since. I then moved to the University of Guelph where I completed a PhD in the lab of Dr. Anthony Clarke. It is here that I developed my interest in carbohydrate chemistry, glycobiology, and carbohydrate recognition. I thoroughly enjoyed my time as a graduate student and looked to expand on my interests in biological mass spectrometry and glycobiology at the National Research Council (NRC) in Ottawa Canada. While working in the group of Dr. Christine Szymanski I developed mass spectrometry tools for glycobiology, specifically in the analysis of lipid-linked oligosaccharides of N-linked protein glycosylation biosynthetic pathways. The resulting methodology was an enabling technology for glycoengineering efforts in bacteria. As an assistant research officer at the NRC I worked on microbial glycomics projects in the pathogen Clostridium difficile and small molecule discovery program for anti-virulence compounds in Helicobacter pylori. Here at 91AV, I have returned to investigating bacterial carbohydrate acting enzymes involved in Gram positive peptidoglycan metabolism and the identification of small molecule inhibitors of these enzymes as chemical biology tools and antimicrobials.

Ph D, University of Guelph

M Sc, University of Waterloo

B Sc, Laurentian University

Gallati, M.,Point, B.,Reid, C. W., Masarimycin an inhibitor of LytG, the major active bacterial GlcNAcase in Bacillus subtilis for the study of bacterial peptidoglycan metabolism, Journal of Visualized Experiments.

Haubrich, B. A.,Nayyab, S.,Williams, C.,Whitman, A.,Zimmerman, T.,Li, Q.,Chen, Y.,Zhou, C.,Basu, A.,Reid, C., Inhibition of Streptococcus pneumoniae autolysins highlight distinct differences between chemical and genetic inactivation, Microbiology.

Smith, A. M.,Papaleo, C.,Reid, C.,Bliss, J. M., RNA-Seq reveals a central role for lectin, C1q and von Willebrand Factor A domains in the defensive glue of a terrestrial slug, Biofouling. The Journal of Bioadhesion and Biofilm Research, 2017.

Reid, C.,O'Connor, M.,Brewster, J.,Gravier, J.,Jamieson, M.,Magno, E.,Miller, R. D.,Phelan, D.,Roohani, K.,Williard, P.,Basu, A., Diamide Inhibitors of the Bacillus subtilis N-acetylglucosaminidase LytG that exhibit antibacterial activity, ACS Infectious Diseases, 2017.

Gutelius, D.,Reid, C., Characterization of SleC a spore specific lytic transglycosylase from Clostridium difficile, .

Menard, R.,Schoenhofen, I.,Tao, L.,Aubry, A.,Bouchard, P.,, .,Lachance, P.,Twine, S.,Fulton, K.,Cui, Q.,Hogues, H.,Purisima, E.,Sulea, T.,Logan, S.,Reid, C., Small-molecule inhibitors of the pseudaminic acid biosynthetic pathway: targeting motility as a key bacterial virulence factor, Antimicrobial Agents and Chemotherapy.

Miller, R.,Gutellius, D.,Holmes, G.,Suter, Z.,Jones, J.,Reid, C.,Hokeness, K., CHARACTERIZATION OF AN ENDO-ACTING N-ACETYLGLUCOSAMINIDASE FROM, .

Hernandez, J.,Duval, J.,Rauff, T.,Hall, E.,Galliti, M.,Haubrich, B. A.,Thoma, M.,Aponte, E.,Basu, A.,DeGeorgis, J.,Reid, C., Chemical Biology Reveals Involvement of N-acetylglucosaminidase LytG In Cell Elongation and Division., ChemRxiv, 2023.

Duval, J.,, N. C.,Reid, C., Breaking Free: Selective Amide Hydrolysis in Monosubstituted Glycine Diamides , Summer Undergraduate Research Symposium, 2023.

Hall, E.,Reid, C., Probing changes to LytG structure in the presence of inhibitors and buffer excipients using UV absorbance spectroscopy, Summer Undergraduate Research Symposium, 2023.

Duval, J.,Rauff, T.,Hall, E.,Reid, C.,, ., Breaking down the role of LytG in Bacillus subtilis peptidoglycan metabolism, 7th New England Glycochemistry Symposium, 2023.

Zeng, J.,Shaw, S.,Reid, C., : Development of a Fluorescent-Based Assay for Characterization of Candida sp. β-(1,3)-Glucan Transglycosylase Phr1, 7th Annual New England Glycochemistry symposium, 2023.

Duval, J.,Rauff, T.,Hall, E.,Reid, C., Breaking down the role of LytG in Bacillus subtilis peptidoglycan metabolism, ACS Northeast Regional Meeting, 2023.

Reid, C.,Ring, P., Development of a Fluorescent Based Assay for Characterization of Candida sp. β-(1,3)-Glucan Transglycosylase Phr1 , American Chemical Society, Fall National Meeting, 2022.

Haubrich, B. A.,Nayyab, S.,Gallati, M.,Hernandez, J.,Williams, C.,Whitman, A.,Zimmerman, T.,Lee, Q.,Chen, Y.,Zhou, C.,Basu, A.,Reid, C., Inhibition of Streptococcus pneumoniae growth by masarimycin, Society of Microbiology, 2022.

Gallati, M.,Point, B.,Reid, C., Synthesis of masarimycin, a small molecule inhibitor of Gram-positive bacterial growth , J Vis Exp, 2022.

Roohani, K.,Haubrich, B. A.,Yue, K.,D'Souza, N.,Montalbano, A.,Rynearson, T.,Menden-Deuer, S.,Reid, C., Trophic upgrading and mobilization of wax esters in microzooplankton, PeerJ, 2019.

Reid, C.,Gravier, M., Business of Chemistry: Using 2nd Generation Biofuels as an Interdisciplinary Project in Scientific Literacy, American Chemical Society, 2016.

Kuhn, H.,Gutelius, D.,Black, E.,Nadolny, C.,Basu, A.,Reid, C., Antibacterial glycosyltriazoles: identification of an N-acetylglucosamine derivative with bacteriostatic activity against Bacillus, Medicinal Chemistry Communications, 2014.

Gutiellus, D.,Logan, S.,Reid, C.,Hokeness, K., Functional Analysis of SleC from Clostridium difficile: an essential lytic transglycosylase involved in spore germination., Microbiology, 2014.

Kratch, J.,Nadolny, C.,Aicardi, K.,Reid, C.,Hokeness, K., The Effects of Fungal Volatile Organic Compounds on Bone Marrow Stromal Cells, Canadian Journal of Microbiology, 2014.

Witkowski, C.,Blais, B.,Feng, L.,Reid, C.,Wang, H.,Yang, H.,Leng, Q., Decay and early diagenesis of Metasequoia leaves: Implications for three-dimensional preservation and bulk isotope signals in plant fossil lagerstätten, 49th Annual Meeting of the Northeastern Section of the Geological Society of America (GSA) Abstracts with Programs, 2014.

Gutelius, D.,Reid, C., Opportunities in Cell Wall Biogenesis, Journal of Glycomics and Lipidomics, 2013.

Bliss, J.,Reid, C., Medical Mycology in the Chemistry Classroom: Germinating student interest in organic chemistry, Journal of Chemical education, 2013.

Witkowski, C.,Feng, L.,Reid, C.,Wang, H.,Yang, H.,Leng, Q., The role of polysaccharides in preserving three-dimensional cell wall structures in plant fossil lagerstätten, 2013 Geological Society of America (GSA) Annual Meeting, Abstracts with Programs, 2013.